Role of Individual Surface Charges of Voltage-Gated K Channels
نویسندگان
چکیده
منابع مشابه
Extracellular Surface Charges in Voltage-Gated Ion Channels.
A large number of charged amino acids are in the extracellularly located parts of the voltage-gated ion channels. Recent findings suggest that these surface charges contribute to the channel functions in the sensing of voltage, the binding of substances, and the sensing of H(+) concentration.
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Inactivation is the process by which an open channel enters a stable nonconducting conformation after a depolarizing change in membrane potential. Inactivation is a widespread property of many different types of voltage-gated ion channels. Recent advances in the molecular biology of K+ channels have elucidated two mechanistically distinct types of inactivation, N-type and C-type. N-type inactiv...
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Typical single channel recordings in voltage-dependent K channels show two simple conductance states: open or shut. Considering the fact that K channels are assembled with four identical subunits, the classical interpretation has been that the conduction pathway is not formed unless all four subunits are in their active positions. In fact, this agrees with the molecular interpretation of the op...
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BACKGROUND Halogenated inhaled anesthetics modulate voltage-gated ion channels by unknown mechanisms. RESULTS Biophysical analyses revealed novel activation of K(v) channels by the inhaled anesthetic sevoflurane. CONCLUSION K(v) channel activation by sevoflurane results from the positive allosteric modulation of activation gating. SIGNIFICANCE The unique activation of K(v) channels by sev...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1999
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(99)76984-5